At the Large Hadron Collider (LHC), the challenge of processing data is daunting. With future aggregate data rates exceeding 1 petabit per second, the data rates at the LHC exceed all other devices in the world. The aim of A3D3 is to build a series of tools that will enable the processing of all of this information in real-time using AI. Through the use of AI, A3D3 aims to perform advanced analyses, such as anomaly detection, and particle reconstruction on all collisions happening 40 million times per second! The National Science Foundation (NSF), under the Harnessing the Data Revolution (HDR) program, is providing funding to establish the Accelerated AI Algorithms for Data-Driven Discovery (A3D3) Institute, a multi-disciplinary and geographically distributed entity with the primary mission to lead a paradigm shift in the application of real-time artificial intelligence (AI) at scale to advance scientific knowledge and accelerate discovery. The Institute team reflects a collaborative effort of Principal Investigators from Caltech, Duke University, MIT, Purdue University, UC San Diego, University of Illinois at Urbana-Champaign, University of Minnesota, University of Washington, and University of Wisconsin-Madison.